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專注于生物學試劑及試劑盒領(lǐng)域
服務(wù)熱線：18101056239
產(chǎn)品型號：K200045M
更新時間：2022-08-15
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Anti-NFKB p65 Monoclonal Antibody
| 英文名稱 | Anti-NFKB p65 Monoclonal Antibody |
|---|---|
| 宿主 | Mouse |
| 別名 | MGC131774;NFKB 3;NFKB3;TF65_HUMAN |
| 應(yīng)用 | WB IHC IP |
| 稀釋比例 | WB 1:1000-3000. IP 1:100-300. IF 1:100-200. IHC 1:200-500. |
| 蛋白分子量 | 65kDa |
| Gene ID | 5970 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG1 |
| 免疫原 | recombinant protein |
| 性狀 | 液體 |
| Public Immunogen Range | recombinant protein |
| Subcellular Locations | Cytoplasm Nucleus |
| Swiss Prot | Q04206 |
| 克隆號 | 5G6 |
| 克隆類型 | Monoclonal Antibody |
| 背景資料 | NFkB p65 is ubiquitinated leading to its proteosomal degradation, which is required for termination of the NFkB response. Phosphorylation of NFkB p65 on S536 stimulates acetylation of K310 by CBP, enhancing transcriptional activity. NFkB p65 is also acetylated at K122, enhancing DNA binding and impairing the interaction with NFKBIA. The protein is deacetylated by HDAC3. Invasion of a host by a pathogen is frequently associated with the activation of NF-kB, which coordinates various aspects of immune function required for resistance to infection. |
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