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產(chǎn)品中心抗體Polyclonal AntibodyK101529PAnti-GCR Polyclonal Antibody
產(chǎn)品型號：K101529P
更新時間：2022-08-15
廠商性質(zhì)：生產(chǎn)廠家
訪 問 量 ：1123
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產(chǎn)品分類
Anti-GCR Polyclonal Antibody
| 英文名稱 | Anti-GCR Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | GCCR;GCR;GCRST;GR;GRL |
| 應(yīng)用 | WB |
| 稀釋比例 | WB 1:3000. |
| 交叉反應(yīng) | Human |
| 蛋白分子量 | 86kDa |
| Gene ID | 2908 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | A synthetic peptide of human GCR |
| 性狀 | 液體 |
| Public Immunogen Range | A synthetic peptide of human GCR |
| Subcellular Locations | Cytoplasm Mitochondrion Nucleus Nucleus |
| Swiss Prot | P04150 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. |
Anti-GCR Polyclonal Antibody
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